245 DICKKOPF-3 CAN REGULATE CARTILAGE DEGRADATION AND CHONDROCYTE CELL SIGNALLING
نویسندگان
چکیده
منابع مشابه
Adenosine Pathways Modulate Chondrocyte Mediated Cartilage Degradation
Introduction: The purine base adenosine (ADO) can function as an extracellular signaling molecule and has been reported to reduce inflammation in several in vivo models (1). Adenosine receptor stimulation increases intracellular accumulation of cAMP and suppresses nitric oxide (NO) synthesis by lipopolysaccharide (LPS)and interleukin-1 (IL-1)-stimulated chondrocytes in monolayer culture (2,3). ...
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OBJECTIVE In vitro models for joint diseases often focus on a single cell type, such as chondrocytes in osteoarthritis (OA) or fibroblast-like synoviocytes (synoviocytes) in rheumatoid arthritis (RA). However, these joint diseases affect the whole joint and interaction between chondrocytes and synoviocytes may play an important role in disease pathology. The current study was designed to study ...
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The view of articular cartilage as a non-regeneration organ has been challenged in recent years. The articular cartilage consists of distinct zones with different cellular and molecular phenotypes, and the superficial zone has been hypothesized to harbour stem cells. Furthermore, the articular cartilage demonstrates a distinct pattern regarding stem cell markers (that is, Notch-1, Stro-1, and v...
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Smooth muscle cells (SMCs) are a key component of healthy and tissue engineered vessels and play a crucial role in vascular development and the pathogenic events of vascular remodeling i.e. restenosis. However, the cell source from which they can be isolated is limited. Embryonic stem (ES) cells that have the remarkable capability to differentiate into vascular SMCs in response to specific stim...
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Introduction Previous studies within our laboratory have shown that supplementation of polyunsaturated n-3 fatty acids (PUFAs), but not other fatty acids have a beneficial effect on reducing the expression and activity of degradative and inflammatory factors known to cause damage and destruction of cartilage in arthritic diseases (1). Data has shown that the expression and activity of degradati...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2011
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(11)60272-0